About Prof. Lobo

Publications

Felix Mahfoud, Michael Böhm, Michel Azizi, Atul Pathak, Isabelle Durand Zaleski, Sebastian Ewen, Kostantinos Tsioufis, Bert Andersson, Peter J. Blankestijn, Michel Burnier, Gilles Chatellier, Sameer Gafoor, Guido Grassi, Michael Joner, Sverre E. Kjeldsen, Thomas Felix Lüscher, Melvin D. Lobo, Chaim Lotan, Gianfranco Parati, Josep Redon, Luis Ruilope, Isabella Sudano, Christian Ukena, Evert van Leeuwen, Massimo Volpe, Stephan Windecker, Adam Witkowski23, William Wijns, Thomas Zeller, Roland E. Schmieder. Proceedings from the European Clinical Consensus Conference For Renal Denervation – Considerations on Future Clinical Trial Design.
European Heart Journal, 1–9.
Tim J Brier, Ajay K Jain, Melvin D Lobo. Central Arteriovenous Anastomosis for hypertension – it’s not all about sympathomodulation. (accepted Future Cardiology Sept 2015)
Lobo, M.D., Sobotka, P. A., Stanton, A., Cockcroft, J. R., Sulke, N., Dolan, E., et al. (2015). Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial.
The Lancet.
Lobo, MD, de Belder MA, Cleveland T, Collier DJ, Dasgupta I, Deanfield J, Kapil V, Knight C, Matson M, Moss J, Paton JFR, Poulter N, Simpson IA, Williams B, Caulfield MJ. Joint UK Societies 2014 Consensus Satement on Renal Denervation. Heart 2015;101:10-16 doi:10.1136/heartjnl-2014-307029
Lobo, MD, Saxena M, Brier T, Kapil V. Resistant Hypertension Treatments – one size does not fit all. CrossTalk Debate – which technique for RHTN. Journal of Physiology Published online 29/10/2014
Julu PO, Shah M, Delamont RS, Collier DJ, Wolff C, Saxena M, Brier T, Holdsworth L, Lobo MD. Response to CB Ablation: CrossTalk Debate – which technique for RHTN. Journal of Physiology Published online 29/10/2014
Wolff, C., Collier, D., Shah, M., Brier, T., Kapil, V., Saxena, M., Lobo, MD. Regulation of blood flow and pressure. Advances in Experimental Medicine and Biology (in press)
Kapil, V., Lobo, MD. Hypertension – pathogenesis, risk factors and prevention. Medicine 2014 (published online 22/07/2014: DOI;)
Burchell, AE., Lobo, MD., Sulke, N., Sobotka, PA., Paton, JF. Arteriovenous Anastomosis: Is This the Way to Control Hypertension? Hypertension 2014; 64: 6-12
Kapil, V., Jain, A.K., Lobo, M.D. Renal Sympathetic Denervation – a review of applications in current practice. Interventional Cardiology Review 2014; 9(1): 54-61.
Lobo, MD. Renal sympathetic denervation: cautious optimism and careful next steps. Br J Cardiol; 2013; 20: 128-129
Paton JF, Sobotka PA, Fudim M, Engelman ZJ, Hart EC, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A. Response to role of the carotid body in obesity-related sympathoactivation. Hypertension. 2013 Jun;61(6):e58
Kapil V, Lobo MD. Clinical Considerations and the Potential for Renal Denervation. Endovascular Today; 2013; 10: 1-7
Rajoo, S., Ng, F., Lobo, M. e-Learning to facilitate Prescribing Skills Assessment (PSA) preparation. Med Educ. 2013 May;47(5):520
Paton, J.F.R., Sobotka, P.A., Hart, E., Burchell, A., Fudim, M., Engelman, Z.J., McBryde, F.D., Abdala, A.P., Marina, N., Gourine, A.V., Baumbach, A., Lobo, M., Partel, N., Nightingale, A. The Carotid body as a therapeutic target for treatment of sympathetically mediated diseases. Hypertension. 2013 Jan;61(1):5-13
Caulfield, M., de Belder, M., Cleveland, T., Collier, D., Deanfield, J., Gray, H., Knight, C., Lobo, M., Matson, M., Moss, J., Poulter, N., Simpson, I., Tomson, C., Williams, B. Joint UK Societies 2011 Consensus Satement on Renal Denervation for Resistant Hypertension
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial Symplicity HTN-2 Investigators. The Lancet, 376;9756:1903 – 1909, (4 Dec 2010)
Donaldson, J., Knowles, C., Hughes, F., Lobo, M. Rectus sheath haematoma associated with low molecular weight heparin: a case series. Ann R Coll Surg Engl. 2007Apr;89(3):309-12.
Lobo, M. Combined formulations in hypertension. Current thinking Supplement, Prescriber Magazine July 2007
Lobo, M. State of the Art: Hypertension. The Practitioner (2002) 246, 408-414
Kabir, J., Lobo, M. Zachary, I. Staurosporine induces endothelial cell apoptosis via Focal Adhesion Kinase (FAK) dephosphorylation and focal adhesion disassembly independent of FAK proteolysis. Biochem. J. (2002) 367, 145-155
Abu-Ghazaleh, R., Kabir, J., Jia, H., Lobo, M., Zachary, I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of Focal Adhesion Kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem. J. (2001) 360, 255-264
Lobo, M., & Zachary, I. Nuclear localisation and apoptotic regulation of an amino-terminal domain focal adhesion kinase fragment in endothelial cells. Biochemical & Biophysical Research Communications, 276 (3):1068-1074, 2000 October 5
Cospedal, R., Lobo, M., Zachary, I. Differential regulation of ERKs 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells. Biochem J (1999) 342, 407-41

Published Abstracts/Oral Presentations

Lobo, MD. The ROX Coupler: Adding Compliance and Reducing Resistance to the Arterial Tree: A Mechanical Treatment for Arterial Hypertension. Results of a Prospective, Randomized, Controlled, Blinded-Endpoint, Multicenter European Trial on Resistant Hypertension.
Oral Presentation: TCT Sept 2014
Worthley, SG., Montarello, J., Saxena, M., Jain, AJ., Walters, D.,Pincus, M., Lobo, MD. Safety and Performance of the EnligHTN Renal Denervation System in Patients with Uncontrolled Hypertension: 1 Month Results of the First 100 Patients in the EnligHTN II Study.
Oral Presentation: European Society of Hypertension June 2014
Lobo, MD., Montarello, J., Saxena, M., Jain, AJ., Walters, D.,Pincus, M., Worthley, SG. Renal Sympathetic Denervation System in Patients with Anti-hypertensive Medication Intolerance and Uncontrolled Hypertension: 1 Month Results of the EnligHTN II Study
Poster Presentation: European Society of Hypertension June 2014
Chan, K., Ng, F., Saxena, M., Collier, D., Matson M, Jain A., Caulfield, M., Lobo, M. Heterogeneous and modest response to renal denervation in resistant hypertension – a prospective case series
Oral Presentation: European Society of Hypertension June 2013
Chan, K., Ng, F., Saxena, M., Collier, D., Matson M, Jain A., Caulfield, M., Lobo, M. Renal Denervation for resistant hypertension – a prospective case series
Poster Presentation: British Hypertension Society Sept 2012
Saxena, M., Collier, D., Caulfield, M., Lobo, M. Resistant hypertension and salt restriction
Oral Presentation: British Hypertension Society Sept 2012
Lidder, S., Ng, F., Gulati, R., Whitehand, A., Perry, L., Lobo, M. Can renin measurement be extended to primary care to inform the stratified medicines approach to hypertension therapy?
Oral Presentation: British Hypertension Society Sept 2012
Rajoo,S., Lobo, M Interactive e-learning to improve intravenous fluid prescribing skills
Poster Presentation: AMEE Conference August 2012
Rajoo,S., Ng, F., Lobo, M. A novel electronic learning tool to facilitate preparation for the Prescribing Skills Assessment
Oral Presentation: Association for the Study of Medical Education July 2012
Rajoo,S., Ng, F., Lobo, M. A novel electronic learning tool to facilitate preparation for the Prescribing Skills Assessment.
Electronic resource contribution: Higher Education Academy Health Sciences 2012 conference
Lidder, S., Ng, F., Gulati, R., Whitehand, A., Perry, L., Lobo, M. Chilling of blood samples for plasma renin activity is not essential – a comparative study
Poster Presentation: ESH 2012
Patel, S., Uddin, I., Ward, A., Ng, F., Caulfield, M., Lobo, M. Plasma renin activity in the South Asian population – an intermediate group
Oral Presentation: British Hypertension Society Sept 2011
PO Julu, M Matson, I Renfrew, MD Lobo A case of failed renal denervation – can autonomic function tests be used to predict response to treatment?
Poster Presentation: BHS Meeting 2011
S. Patel, I. Uddin, A. Ward, F.L. Ng, M.J. Caulfield, M.D. Lobo Salt intake in hypertensive patients with at or above-target blood pressures
Oral Presentation: British Hypertension Society Sept 2011
Rull, G., Arunachalam, G., Wadley, J., Mandersloot, G., Lobo, M. Severe uncontrolled hypertension treated with microvascular decompression of the brainstem.
Oral Presentation: British Hypertension Society Sept 2007
Arunachalam, G., Emery, M., Lobo, M. A rugby player with collapse.
Oral presentation: European Federation of Internal Medicine 2007
Lobo, M., Ravic, N., Forte, P,. Milne, E., Lewis, G., Webb, A., Hedges, A.M., Benjamin, N. Effect of Quinapril and Losartan on Nitric Oxide Synthesis in Patients with Essential Hypertension. American Society of Hypertension. 2004.
Lobo, M., Zachary, I. Subcellular compartmentalisation, site-specific tyrosine phosphorylation and apoptotic proteolysis of Focal Adhesion Kinase in Human Umbilical Vein Endothelial Cells. Mol. Biol. Cell 1999 10:S, 335a
Lobo, M., Zachary, I. Constitutive nuclear localisation of Focal Adhesion Kinase in rabbit vascular smooth muscle cells. British Society for Cardiovascular Research. 1998
Lobo, M., Zachary, I. Increased protein expression of focal adhesion components during early stages of smooth muscle cell explant culture. 10th International Vascular Biology Meeting. 1998

Case Reports

Ghadiri-Sana, M., Mann, I., Lobo, M., Jawad, A. Secondary syphilis presenting as palmoplantar psoriasis. J R Coll Physicians Edinb 2008; 38:215–7
Everett, CM., Turner, B., Lobo, M. Posterior reversible encephalopathy syndrome in (low renin) essential hypertension. J R Soc Med. 2007 Nov;100(11):522-3.

Book Chapters

Contributing author: Cardiovascular Sections (12 chapters), French’s Index of Differential Diagnosis, 15th Edition Eds. Kinirons and Bouchier. (Published 28/01/2011)
Contributing author: Cardiovascular Sections (12 chapters), French’ Index of Differential Diagnosis (14th Ed. Published 25/11/2005) Eds. Kinirons and Bouchier.